For example, the Class I PI3K catalytic MTOR subunit genes pik3cd and pik3cg are upregulated 8.5-fold and 2.5-fold, respectively, while the expression of akt1 increases 3.5-fold, and that of akt2 and akt3 increases 2-fold, during OM [25]. This evidence concerns the gene PIK3CG and ocular melanoma.