HIF1A and colorectal carcinoma: Exosomes derived from hypoxic bone marrow-derived MSCs mediated transfer of miRNAs, including miR-193a-3p, miR-210-3p and miR-5100, from bone marrow-derived MSCs to lung cancer cells, increased the expression of total and phosphorylated STAT3, thus promoted invasion of lung cancer cells by activating STAT3 signaling-induced EMT.140 Hypoxia-induced CRC-derived exosomes, containing miR-23a, which could lead to the down-regulation of PDH1/2 when applied to CRC cells, thus eventually upregulated HIF-1α, an independent activator of EMT.141