Further research demonstrated that exosomal miR-106b-3p can increase lung metastasis of CRC cells via Vimentin, N-cadherin upregulation and E-cadherin down-regulation by targeting DLC-1 (Deleted in Liver Cancer-1) gene.121 In pancreatic ductal carcinoma(PDAC), lncRNA-Sox2ot was identified from highly invasive PDAC cells, and plasma exosomal Sox2ot expression was closely associated with TNM stage and overall survival rate of PDAC patients. This evidence concerns the gene DLC1 and pancreatic ductal adenocarcinoma.