DLC1 and colorectal carcinoma: Further research demonstrated that exosomal miR-106b-3p can increase lung metastasis of CRC cells via Vimentin, N-cadherin upregulation and E-cadherin down-regulation by targeting DLC-1 (Deleted in Liver Cancer-1) gene.121 In pancreatic ductal carcinoma(PDAC), lncRNA-Sox2ot was identified from highly invasive PDAC cells, and plasma exosomal Sox2ot expression was closely associated with TNM stage and overall survival rate of PDAC patients.