NOTCH3 and breast cancer: It also promoted tube formation and cell migration of BxS (GEM-sensitive BxPC-3 cells) and PANC-1 cells.87 In breast cancer, RAB27B promoted exosomes transfer from stromal cells to breast cancer cell with the transfer of exosomal 5′-triphosphates which activated the RIG-I (retinoic acid-induced gene 1 enzyme) signal in target cells, thereby activating IRDS (Interferon-Related DNA Damage Resistance Signature) genes, in parallel activation of the NOTCH3 pathway to regulate the expansion of therapy-resistant tumor-initiating cells known as CSCs.88