And Hsp90 plays a crucial role in promoting tumor growth and metastasis of breast cancer, pancreatic cancer (PC), leukemia, and closely associated with poor prognosis of tumors.29 Additionally, for exosome-related functions, a recently research showed that membrane deformability of Hsp90 mediates fusion of MVBs and plasma-membrane.30 The exosomes lack of extracellular Hsp90α, a key subtype of Hsp90, will lose the capacity to carry out the important intercellular communication from tumor cells to stromal cells, which promoting cellular motility.31 Here, HSP90AA1 is linked to pachyonychia congenita.