The exosomes could subsequently be ingested by endothelial cells, and delivering lncRNA H19 to the corresponding target cells by adhesion to CD90 cells and HUVECs, and stimulating angiogenesis by the synthesis and release of vascular endothelial growth factors.57 lncRNA also plays an important role in tumor resistance.58 UCA1 (a lncRNA) activated the Wnt signaling pathway and promoted cisplatin resistance in bladder cancer cells by increasing the expression of Wnt6. This evidence concerns the gene UCA1 and urinary bladder carcinoma.