And Hsp90 plays a crucial role in promoting tumor growth and metastasis of breast cancer, pancreatic cancer (PC), leukemia, and closely associated with poor prognosis of tumors.29 Additionally, for exosome-related functions, a recently research showed that membrane deformability of Hsp90 mediates fusion of MVBs and plasma-membrane.30 The exosomes lack of extracellular Hsp90α, a key subtype of Hsp90, will lose the capacity to carry out the important intercellular communication from tumor cells to stromal cells, which promoting cellular motility.31 The gene discussed is HSP90AA1; the disease is neoplasm.