In this regard, MM is defined by chronic endoplasmic reticulum (ER) stress induced by a continuous and high production of monoclonal immunoglobulin; in order to maintain ER homeostasis and survival, MM cells express high levels of ER chaperones, such as GRP78, BiP and Grp94, and activate the UPR pathway. Here, HSPA5 is linked to Miyoshi myopathy.