RUNX1 and Ewing sarcoma: In contrast, expression of the oncogenic fusion proteins AML1-ETO (RUNX1-RUNX1T1) or BCR-ABL1 under the hsp70 promoter is responsible for the development of myeloid leukemia-like lesions after the heat shock of the transgenic embryos [181,182], whereas expression of the human EWS-FLI1 (EWSR1-FLI1) fusion oncoprotein under the hsp70 promoter induces tumors with histology strongly resembling that of human Ewing’s sarcoma in heat shock-treated zebrafish [183].