RAG2 and acute lymphoblastic leukemia: Similarly, using the rag2 promoter to drive the expression of Cas9 and the Notch1aICD oncogene into immature T-cell progenitors, the Alejandro Gutierrez group (Boston Children’s Hospital, Boston, MA, USA) showed that inactivation of ptch1 accelerates the Notch1aICD-induced T-ALL onset [84].