A transgenic Tg(UAS:GFP-HRASG12V) line develops melanoma when crossed with lines expressing Gal4 under the kita enhancer [166], leukemia when crossed with lines expressing Gal4 under the fli1 promoter [167], glioma when crossed with lines expressing Gal4 under the zic4 enhancer [168] or chordoma when crossed with lines expressing Gal4 under the notochord-specific promoter shhb (also known as twhh, tiggywinkle hedgehog) promoter [169]. The gene discussed is LGALS4; the disease is central nervous system cancer.