In summary, large-scale genetic screens in zebrafish successfully resulted in the identification of lines displaying mutations in orthologues of mammalian tumor suppressor genes such as NF2 or TP53, as well as in the discovery of a variety of genes that were not previously linked to cancer, including among others, mybl2, dnnaf1 or multiple genes encoding ribosomal proteins (Table 2). This evidence concerns the gene NF2 and cancer.