For instance, while the ptf1a (pancreas associated transcription factor 1a) promoter is active in cerebellum, hindbrain and pancreas, Tg(ptf1a:Gal4; UAS:KRASG12V) double-transgenics develop pancreatic tumors [170], whereas Tg(ptf1a:Gal4; UAS:AKT1Myr) present glioma [171]. This evidence concerns the gene PTF1A and central nervous system cancer.