Herein, we found that treatment with moderate (0.5 and 1 μM) and high (2 μM) concentrations of EF-24 with HL-60 AML cells increased and decreased the phosphorylation status of PP2A-Cα, respectively (Figure 5A,B), suggesting that declining and upregulated PP2A activities are dependent on different concentrations of EF-24 treatment. Here, PTPA is linked to acute myeloid leukemia.