In the current study, we first evaluated the cytotoxic effects of DMC and EF-24 in HL-60, U937, and MV4-11 AML cell lines, which harbor the wild-type (WT) or mutant form of FLT3 and NRAS (FLT3-WT or FLT3-internal tandem duplication (ITD) and NRAS-WT or NRAS Q61L mutation). The gene discussed is FLT3; the disease is acute myeloid leukemia.