Similar benefits were obtained using glucagon-like peptide 1 receptor agonists (GLP1RAs) in experimental models, including protection against hyperglycemia-induced inflammation, oxidative stress, BRB breakdown, angiogenesis, and neurodegeneration, which seems to be at least in part mediated by the AKT pathway [195,196,197]. This evidence concerns the gene AKT1 and Hyperglycemia.