Isolated from the red alga Polysiphonia morrowii, 3-bromo-4,5-dihydroxybenzaldehyde 5.1 (also 2.30, 3.8, 4.9, and Scheme 5) was reported to alleviate IgE-mediated inflammatory responses in an atopic dermatitis mouse model and RAW 264.7 macrophages, suggesting their therapeutic potential for treating allergic inflammation, e.g., atopic dermatitis [102]. The gene discussed is IGHE; the disease is atopic eczema.