Gene expression analysis unveiled significant differences in the expression of molecular pathways between EAC and ESCC: CDH1 signaling together with E-cadherin regulator ARF6 and FOXA pathways are upregulated in EAC, while ESCC is associated with the upregulation of Wnt, syndecan and p63 pathways [29]. This evidence concerns the gene ARF6 and esophageal squamous cell carcinoma.