Other genes deleted in ESCC are LRP1B (2q22.1–22.2), TNFRSF10A (8p21.3), PDE4D (5q12.1), PTPRD (9q24.1), FHIT (3q14.2), RB1 (13q14.2), PTEN (10q23.21), PIK3R1 (5q13.1), FAT1 (4q35.2), ZNF750 (17q25.3), CUL1 (7q36.1), CUL5 (11q22.3) and VGLL4/ATG7 (3p25.2) [29,31,33,35]. Here, FHIT is linked to esophageal squamous cell carcinoma.