Four SMGs in ESCC involved in chromatin remodeling have been discovered: MML2 (mutated in 11 to 19% of ESCC), KDM6A (3–7%), EP300 (8–13%) and BAP1 (less than 5%) [25,26,28,32,33]. The gene discussed is EP300; the disease is esophageal squamous cell carcinoma.