In vitro, treatment with antioxidants (e.g., retinoic acid) reduces ROS (via increased transcription of the ROS-scavenger glutathione peroxidase) and apoptosis in response to exogenous oxidative stress (H2O2 exposure) in human FSHD myoblasts, as well as DUX4-induced toxicity in C2C12 myoblasts, suggesting that antioxidant treatment could positively affect plasma membrane repair capacity [38,39]. Here, DUX4 is linked to facioscapulohumeral muscular dystrophy.