DUX4 and facioscapulohumeral muscular dystrophy: Based on previous research demonstrating the central role of DUX4 and reduced ability of FSHD cells to handle increased oxidative stress [25,26], we showed that lowering DUX4 expression with antisense oligonucleotides, and a membrane associating antioxidant/ROS-scavenger (Trolox), significantly improved repair in FSHD myoblasts.