SLC22A12 and hyperuricemia: Figure 1 provides an overview of selected variants of the SLC2A9 and SLC22A12 genes that are associated with hyperuricemia and gout, or vice versa, with hypouricemia. None of the variants found in our cohort were associated with hypouricemia, which is not surprising in light of the characteristics of our cohort and also because renal hypouricemia is a very rare disease [29,30].