CCND1 and Miyoshi myopathy: According to the major genetic and genomic studies of MM cells, three events altering chromosomal ploidy and stability are involved at the origin of MM: (i) Hyper-diploidy (HD), mainly related to trisomies, (ii) non-hyper-diploidy (NHD), related to 14q32 IGH chromosomal translocations, mainly t(4;14), and (iii) a particular driving event, t(11;14), mainly associated to diploidy (D) and involving CCND1. Of note, these early chromosomal alterations are not only present in MM cells, but also in the memory B cells of patients with MM, and in MGUS cells [32].