They retrospectively evaluated tumor vascularity and expression of components of VEGF pathway and hypoxic response as predictive markers for radiographic response and survival in tumor expression of VEGF-A, VEGFR-2, CD31 hypoxia-inducible cardonic anhydrase 9 (CA9), and hypoxia-inducible factor-2a (HIF-2a) were semi quantitatively assessed by immunohistochemistry (IHC). The gene discussed is CA9; the disease is neoplasm.