They retrospectively evaluated tumor vascularity and expression of components of VEGF pathway and hypoxic response as predictive markers for radiographic response and survival in tumor expression of VEGF-A, VEGFR-2, CD31 hypoxia-inducible cardonic anhydrase 9 (CA9), and hypoxia-inducible factor-2a (HIF-2a) were semi quantitatively assessed by immunohistochemistry (IHC). This evidence concerns the gene EPAS1 and neoplasm.