ZEB2 and melanoma: One can hypothesize that ZEB2 expression follows a model mirroring the MITF rheostat: ectopic expression of ZEB2/MITF in melanoma cells would result in differentiation and cell cycle arrest, while ZEB2/MITF silencing would also result in proliferation defects, an intermediate level of ZEB2/MITF would sustain proliferation of melanoma cells.