Similarly, in the BRAF; PTEN melanoma mouse model, when tumors are induced on the tail, which better mimics the melanoma transition from a radial to a vertical growth phase [59], the loss of differentiation markers (such as MITF) in a subset of epidermal melanoma cells, before the dermal invasion, was shown to be associated with ZEB1 activation, reinforcing the role of ZEB1 in this transition. This evidence concerns the gene PTEN and melanoma.