Each tracer has different uptake features: radiolabeled Cho and acetate are markers of the cell membrane synthesis; PSMA is a membrane antigen overexpressed in the majority of PCa cells, and it is a target for a variety of urea-derived agents; fluciclovine uptake is related to functional activity of amino acid transporters; fluoride and 18F-FDG mark the metabolism of bone matrix and cell glucose, respectively [1]. This evidence concerns the gene FOLH1 and posterior cortical atrophy.