As demonstrated by von Eyben et al. [12], radiolabeled Cho PET/CT detected metastatic sites in patients with BR-PCa and PSA levels > 1 ng/mL at a clinically relevant level, without a significant impact of types of Cho radiotracers (11C-Cho or 18F-Cho) and different acquisition protocols on the detection rate. Here, KLK3 is linked to posterior cortical atrophy.