APP and Alzheimer disease: For example, the alkalinisation of lysosomes, induced by chloroquine treatment or by blockade of the v-ATPase pump using bafilomycin A1, can lead to an increased release of exosomes (positive for CD63, Tsg101, and Alix) and of pathological proteins including those related to AD, such as C99, AICD, and Aβ [59,61,173,179,180,181,182].