Autoantibody profiles may be heritable, and autoantibody associations for AA SLE patients have been demonstrated for alleles of LRRC20, LPAR1, EFNA5, and VSIG2 to anti-SSB, anti-SSA/Sm, anti-RNP, and anti-RNP/Sm–, respectively (65). This evidence concerns the gene RNPC3 and systemic lupus erythematosus.