RNPC3 and systemic lupus erythematosus: For all 3 ancestries, patients positive for both anti-RNP and anti-dsDNA plus any of the other 3 autoantibodies had significantly increased enrichment scores for plasma cells, IGS, Ig, cell cycle, Treg, myeloid-secreted, and antiinflammation signatures compared with SLE patients negative for all 5 autoantibodies (Figure 4C).