Similar to female SLE patients, significantly increased IGS GSVA scores were determined for males with anti-RNP and anti-dsDNA plus any of the other 3 autoantibodies, and with RNP+dsDNA– versus anti-dsDNA+ plus any of the other 3 autoantibodies, and all of these groups were significantly different from patients with none of these 5 autoantibodies (Supplemental Figure 2B). This evidence concerns the gene RNPC3 and systemic lupus erythematosus.