CD4 and systemic lupus erythematosus: Although there was no difference in AA and EA T cell GSVA enrichment scores, several genes reported to be hypomethylated in AA compared with EA CD4+ T cells were also overexpressed in AA compared with EA in both healthy and 3 of 4 SLE comparisons, including IL32, CDKN1A, SLC2A1, and WIPI2. We were not able to confirm the apoptosis-related genes reported to be hypomethylated in CD4+ T cells, as only CDKN1A and TNFRSF10A (2 SLE data sets) of the 10 apoptosis-related genes were differentially expressed between AA and EA controls or SLE patients (60).