CD4 and neoplasm: Six days after LLC tumor implantation, mice were given RAD001 daily at 0.01 mg/kg or 0.05 mg/kg or vehicle control for 8 days, followed by adoptive transfer of preactivated Thy1.1+ (OT-I) CD8+ and OT-II CD4+ T cells expressing the IFN-γ–yellow fluorescent protein (YFP) reporter (28–30).