RPTOR and neoplasm: To determine potential molecular mechanisms by which endothelial Raptor/mTORC1 may dysregulate TIL activity, LLC tumor lysates from RaptorECKO mice and their RaptorWT sex-matched littermate controls (6 KO-WT pairs) were screened for cytokine and chemokine production by Luminex multiplex assay (Figure 6A).