As shown in Fig. 4F, at 4 days postinfection, UL138 expression was increased in cells infected with the ΔmiR-US5-2 mutant virus, but was reduced in cells infected with the ΔmiR-US5-2/GAB1shRNA virus, indicating that through targeting GAB1, miR-US5-2 modulates UL138 expression during viral infection. The gene discussed is GAB1; the disease is viral infectious disease.