GAB1 and viral infectious disease: To assess the role of miR-US5-2 targeting of GAB1 in UL138 expression in the context of viral infection, we generated a miR-US5-2 knockout virus (ΔmiR-US5-2; 8) and a virus where miR-US5-2 was replaced with an shRNA targeting GAB1 (as identified in Fig. 1E) (ΔmiR-US5-2/GAB1shRNA).