Finally, low levels of angiopoietin 1 (Ang1) and elevated levels of its antagonist angiopoietin 2 (Ang2) have been associated with dengue vascular leakage (5, 37), and the Ang1/Ang2 ratio has been proposed as a diagnostic marker for patients at risk of developing severe dengue (38). This evidence concerns the gene ANGPT2 and dengue disease.