Vascular endothelial growth factor promotes wound healing through several mechanisms, including collagen deposition, angiogenesis and epithelialisation.18 Thus, it is notable that there was no difference between nintedanib and placebo in net digital ulcer burden.5 No indication of aggravation of PH, cardiac failure or pulmonary haemorrhage was observed in patients with PH treated with nintedanib. The gene discussed is VEGFA; the disease is Pulmonary hemorrhage.