For functional validation, we screened a focused library of 39 epigenetic inhibitors (SI Appendix, Table S2) to study their effect on the expression of key profibrotic genes (ACTA2, COL1A1, COL3A1, and TGFB1) on early passage myofibroblasts derived from nodules in patients with DD (Fig. 1B and SI Appendix, Fig. S1). The gene discussed is ACTA2; the disease is dentin dysplasia.