CREBBP and dentin dysplasia: This unsupervised network connectivity analysis identified FoxO and WNT signaling as highly ranked pathways that share CREBBP and EP300 member genes, as shown at the intersection of delineated pathways in blue and green, respectively (Fig. 1A and SI Appendix, Table S1), providing unbiased support for our hypothesis that epigenetic modulators are important in controlling disease processes in DD.