COL1A1 and dentin dysplasia: For functional validation, we screened a focused library of 39 epigenetic inhibitors (SI Appendix, Table S2) to study their effect on the expression of key profibrotic genes (ACTA2, COL1A1, COL3A1, and TGFB1) on early passage myofibroblasts derived from nodules in patients with DD (Fig. 1B and SI Appendix, Fig. S1).