ALK融合基因阳性NSCLC患者诊断时大约30%有中枢神经系统(central nervous system, CNS)转移,LM发生率为10.3%[45],关于ALK阳性及ROS-1阳性LM治疗的研究很少。. The gene discussed is ROS1; the disease is non-small cell lung carcinoma.