DUOX1 and viral infectious disease: At present, no evidence is available for a role of Se or selenoproteins in modulating NOX and DUOX activity in relation to viral infections; however, supplementation with selenomethionine has been shown to protect lung tissue against toxic effects of ionising radiation by reducing DUOX1 and 2 gene expression and IL-4 and IL-4 receptor subunit α-1 protein levels(40).