Both conditions are highly prevalent among the elderly with and without cognitive deficit [30, 31]; however, of these two, HS-TDP-43 (also known as limbic-predominant age-related TDP-43 encephalopathy (LATE) [32]) is the more likely etiology due to the lack of tau binding in the medial temporal lobes which is expected in PART. This evidence concerns the gene TARDBP and Cognitive impairment.