Resveratrol was found to modulate SIRTs’ activity (SIRT 1,2,3,5) especially as a SIRT1 activator, 5' AMP-activated protein kinase (AMPK), protein kinase C, NF-kB, p53, activator protein 1 (AP-1), early growth regulator 1 (EGR-1), sterol regulatory element-binding protein 1 (SREBP-1), and DNA methyltransferase (DNMT)1 thus targeting the regulation of viral infection [22, 57]. Here, SREBF1 is linked to viral infectious disease.