Hypermethylation of the genes G protein-coupled receptor 180 (GPR180), macrophage stimulating 1 receptor (MST1R), OCIA domain containing 2 (OCIAD2), and poly (ADP-ribose) polymerase family member 6 (PARP6) was also involved in the tumorigenesis of HB, and methylation status was significantly correlated with metastasis [55]. Here, GPR180 is linked to hemoglobin measurement.