AGT and fibrosis: While control animals showed no difference in fibrosis over time we observed an increase in myocardial fibrosis in animals exposed to the angiotensin II infusions compared to control animals (4.4, [3.5, 5.8] vs 10.1 [8.7, 12.9] % and baseline (4.5, [3.5, 5.8] vs 10.1 [8.7, 12.9], both p < 0.001).