The MTHFR C677T polymorphism was an independent predictor of the severity of lesions as shown in Table 5 (TT vs. CC + CT for atrophy: odds ratio [OR] = 2.18; 95% confidence interval [CI], 0.93–5.09; P = 0.07; for IM: OR = 3.39; 95% CI, 1.27–9.06; P = 0.02; for moderate-to-severe lesions: OR = 3.84; 95% CI, 1.24–11.90; P = 0.02; for OLGA: OR = 3.98; 95% CI, 1.54–10.23; P = 0 .004; and for OLGIM: OR = 2.45; 95% CI, 1.05–5.76; P = 0.039). This evidence concerns the gene MTHFR and Atrophy.