First, the IL-6 values observed in the AIS + D group here (median 11.5 pg/mL with IQR 8.3) were higher than those observed by Hotter et al. in a series of 94 patients with acute stroke alone (median 2.8 pg/mL, IQR 3.2, on admission) [20], and similarly, the CRP values observed in the AIS + D here (median 19.8 mg/L with IQR 28.6) were higher than the values associated with severe strokes in the 316 patients studied by Luo et al. (≥ 7 mg/L) [21]. This evidence concerns the gene CRP and stroke disorder.