The latter included an up-regulated gene associated with promoting non-cap dependent mRNA translation (eif5b) and several down-regulated ribosomal subunits, two down-regulated histone subtypes associated with transcriptional activation, a down-regulated mitotic check point protein (hp1bp3), and an up-regulated C/EBP-related transcription factor (ddit3) that is regulated by stress factors associated with bacterial infections and with mammalian optic nerve injury but which had not previously been implicated in successful CNS axon regeneration [34, 101]. This evidence concerns the gene DDIT3 and bacterial infectious disease.