CYP3A4 and hypertensive disorder: Consistent with published clinical data regarding N. sativa and fenugreek in combination or alone, the consumption of NFC had no adverse effect on hepatic, kidney, or thyroid functioning.15,28,60,61 While in vitro and animal studies describe the potential for an interaction of N. sativa or fenugreek phytoceuticals with drugs metabolized by hepatic CYP3A4,62,63 in our study one subject receiving metoprolol (a CYP3A4 substrate) therapy for hypertension maintained readings of 120, 80, 40, and 93 mmHg for SBP, DBP, PP, and MAP, respectively, from baseline through 12 weeks.