Therefore, the regulatory network (Figure 7A) based on GATA6 (the most significant TF), COL3A1 (DEIG), CCR (immune pathway), Treg (immune cell), APC‐co‐stimulation (immune pathways), DC (immune cell), check‐point (immune pathway), T‐cell co‐stimulation (immune pathway), type II IFN response (immune pathway), macrophage (immune cell), Th2 cell (immune cell), propanoate metabolism (KEGG pathway), systemic lupus erythematosus (KEGG pathway) and proteasome (KEGG pathway) was established. The gene discussed is GATA6; the disease is systemic lupus erythematosus.