By validation based on qPCR, COL3A1 correlated with prognosis of GBM, and the expression level was related to the grade of glioma (normal vs LGG, P < 0.001; normal vs higher grade glioma (HGG), P = 0.002; LGG vs HGG, P = 0.005).1 This evidence concerns the gene COL3A1 and central nervous system cancer.