After the initial suggestion that lymphatic dysfunction would lead to obesity in mice, findings in humans reinforced this hypothesis: genome‐wide association studies in Asian populations identified one single‐nucleotide polymorphism (SNP) (rs1704198) near the PROX1 gene that is linked with increased waist circumference (Kim et al., 2013). This evidence concerns the gene PROX1 and obesity due to melanocortin 4 receptor deficiency.