According to the Online Mendelian Inheritance in Man database (www.omim.org), variants in six genes have been associated with this phenotype (CALCRL, EPHB4, GJC2, FLT4, PIEZO1, and VEGFC); other genes responsible for inherited syndromes that include lymphedema among their clinical signs are also listed in OMIM. The gene discussed is CALCRL; the disease is lymphedema.