The significantly low tumor uptake of [68Ga]Ga-DOTA-ST8950 in HEK-SST-negative xenografts (1.4 ± 0.5 %IA/g), versus 26 ± 8 %IA/g in HEK-SST2 tumors and 15 ± 6 %IA/g in HEK-SST5 tumors at 1 h p.i. confirms the receptor-mediated uptake (specificity) of [68Ga]Ga-DOTA-ST8950. Here, SST is linked to neoplasm.