Our study demonstrated overexpression of CXCR4 in several types of non-Hodgkin lymphoma with [68Ga]pentixafor PET/CT, including lymphoplasmacytic lymphoma, marginal zone lymphoma, DLBCL, follicular lymphoma, mantle cell lymphoma, unclassified indolent B cell lymphoma, and EATL. Here, CXCR4 is linked to mantle cell lymphoma.