MKI67 and Cowden syndrome 1: Univariable analysis identified age (HR 1.06), WHO performance score of 2 (HR 4.0), Ki-67 ≥ 10% (HR 1.3), grade 2 tumours (HR 1.8), an unknown primary tumour (HR 1.3), distant (HR 2.2) and liver metastases (HR 2.5), the presence of CS (HR 1.7) and CHD (HR 2.3), elevated CgA > 6 ULN (HR 4.3) and any elevated liver test (HR 4.9) to be associated with actual DSS (Table 2).