MKI67 and neoplasm: In multivariable analysis age (HR 1.07), WHO performance status of 2 (HR 4.4), an unknown primary tumour (HR 3.2), Ki-67 index ≥ 10% (HR 12.6), CgA > 6 times ULN (HR 3.2) and elevated liver tests (HR 3.1) remained independent predictors for DSS in both the imputed as well as the non-imputed dataset.