Interestingly, this SNP alone has no impact on the BC risk, but the authors described a gene–gene interaction between MSH4 Ala97Thr and MLH3 Leu844Pro (rs5745325 and rs175080, respectively), resulting in an increased BC susceptibility (A/G genotype of MSH4 with A/A genotype of MLH3 (OR = 2.35, 95% CI = 1.23–4.49, p = 0.01), G/G genotype of MSH4 with A/A genotype of MLH3 (OR = 2.11, 95% CI = 1.12–3.98, p = 0.02) and G/G genotype of MSH4 with A/G genotype of MLH3 (adjusted OR = 1.88, 95% CI = 1.12–3.15, p = 0.02)). Here, MSH4 is linked to breast cancer.