MSH3 and carcinoma of esophagus: SNP rs1042821 was associated with decreased risk of primary hepatocellular cancer, and together with MSH3 rs26279 (Ala1045Thr) with decreased risk of oesophageal cancer; patients carrying the heterozygous G/A genotype of rs1042821 did not display higher risk of CRC (OR = 1.65, 95% CI = 1.01–2.69, p = 0.44) [124,125].