The authors showed that women with binary SNP interaction of rs2059520 or rs2303428 with rs1800734 in MLH1 (accounting for ~9% of all endometrial cancer cases) had a particularly higher risk of this cancer, compared to those bearing wild type (WT) variants of these SNPs (OR = 2.1, 95% CI = 1.2–3.6, p = 0.005) [39]. The gene discussed is MLH1; the disease is endometrial cancer.