Among 68 SNPs in seven MMR genes, 10 appeared significant in the univariate analysis (p < 0.05), but after adjustment for sex, age, stage and diagnosis, only rs863221 in MSH3 gene remained associated with better OS in CRC patients (HR = 0.59, 95% CI = 0.42–0.82, p = 0.001) [95]. This evidence concerns the gene MRC1 and colorectal carcinoma.