Another intronic SNP, rs5742938 (c.-21+639G>A), was associated with increased risk of oesophageal cancer in South Africans with mixed ancestry (G/G versus A/A or A/G: OR = 1.73, 95% CI = 1.07–2.79, p = 0.027), but with no effect on the PMS1 mRNA expression levels [127]. This evidence concerns the gene PMS1 and carcinoma of esophagus.