Interestingly, common G/G variant of rs7797466 increased the risk of CRC when combined with G/A variant of MSH6 SNP rs1042821, as investigated in a Polish case–control study of 200 patients and 200 controls (OR = 1.65, 95% CI = 1.01–2.69, p = 0.44) [124]. This evidence concerns the gene MSH6 and colorectal carcinoma.