Both splenic diffuse red pulp lymphoma (SDRPL), and HCLv are considered “splenic B-cell lymphoma/leukemia, unclassifiable” [35], although SDRPL has less lymphocytosis, anemia, longer overall survival from diagnosis, brighter CD123, and lower CD11c and CD103 expression [35]. The gene discussed is ITGAX; the disease is splenic diffuse red pulp small B-cell lymphoma.