The third study [15] evaluated 30 participants with type 2 diabetes and periodontitis (15 intervention and 15 placebo) but found no reduction in the concentration of IL-1β between baseline and three months (it remained at mean (standard error [SE]) of 0.3(0.3) pg/mL); however, the study authors did not give separate results for the intervention and placebo groups. The gene discussed is IL1B; the disease is type 2 diabetes mellitus.