In the second study [26], the SDD significantly reduced the odds of increased MMP-8 levels by 60% compared to placebo during the two-year period of study (OR 0.40, 95%CI: 0.21 to 0.77, p = 0.006) among the 128 postmenopausal women with periodontitis (64 in each group). The gene discussed is MMP8; the disease is periodontitis.