TIMP1 and chronic periodontitis: One study [31] reported TIMP-1 and found no significant difference between the antibiotic group (SDD) and placebo group: TIMP-1 among the 128 postmenopausal women with chronic periodontitis after two years; ratio of medians of SDD versus placebo (0.96, 95%CI: 0.78 to 1.18, p = 0.7), according to study authors.