The authors then performed a dual blockade of LAG-3 and CTLA-4 in PD-1 knockout mice, which resulted in an increase in tumor free survival to 40% of mice, as well as an increase of peritoneal CD8+ T cells and cytokine producing effector T cells, and a decrease in Tregs and MDCS [104]. The gene discussed is PDCD1; the disease is neoplasm.