GREM1 and Abnormal intestine morphology: Despite a recently published study by Rowan et al. that determined that Grem1 depletion in vivo resulted in severe enteropathy and rapid onset BM failure in adult mice [46], the data from this study and a previous study by Ciuclan et al. have demonstrated that anti-Grem1 antibody treatment is well tolerated, with no adverse effects reported in any experimental animals [45].