In both of these models, injection of the Vk*MYC transplants or 5TGM1 murine MM cell line intravenously into young syngeneic C57BL6 and KaLwRij mice, respectively, results in the development of disease that recapitulates many features of human disease, including PC growth within the BM, lytic bone disease, and paraprotein production [31,32]. Here, MYC is linked to Miyoshi myopathy.