In PCa, higher expression levels of CASC2 prevented miR-183 from binding to the 3′UTR of sprouty RTK signaling antagonist 2 (SPRY2) by acting as a ceRNA, thus preserving SPRY2 expression and inhibiting the downstream ERK signaling pathway, which is linked to chemoresistance [35,192] (Figure 3C). This evidence concerns the gene SPRY2 and posterior cortical atrophy.