For example, using an EDB-FN-specific peptide probe, ZD2-Cy5.5, we previously showed that invasive cancer cell lines, e.g., PC3 (prostate) and MDA-MB-231 (hormone receptor-negative breast cancer), are EDB-FN-rich, while the less invasive cancer cell lines, e.g., LNCaP (prostate) and MCF7 (hormone receptor-positive breast) exhibit significantly lower EDB-FN levels [18,22,23,24]. The gene discussed is FN1; the disease is cancer.