Many splicing factors have been shown to have a role in breast cancer and to promote its progression, including SRSF1 [30,47,48], SRSF3 [49], SRSF5 [50], SRSF6 [40,41,42], SRSF10 [51], HNRNPA1 [33], HNRNPA2B1 [34,35,52], HNRNPM [53], HNRNPK [36,37], HNRNPL [54], RBFOX2 [55], ESRP1/2 [55], PTBP1 [38,39] RBM5/10 [56], Sam68 [57] and FOX2 [58]. The gene discussed is RBM5; the disease is breast cancer.