In addition to being byproducts of glycolysis, glyoxal and methylglyoxal come from food sources, yet it is tantalizing to speculate that MR1-expressing cancer cells undergo increased glycolysis to produce glyoxal and methylglyoxal, which react with vitamin B metabolites to form the antigen or antigens that bind MR1 and are recognized by the TCRs of MR1T cells. Here, MR1 is linked to cancer.