LEP and metabolic disease: Knowing that, in obesity, and in parallel with the increased secretion of leptin from adipose tissue, there is a disturbed adipose tissue secretory pattern characterized by an increased release of pro-inflammatory factors and decreased production of anti-inflammatory adipokines [42] and associated with the development of obesity-associated comorbidities, we hypothesize that inflammation can also contribute to the CB dysfunction that is involved in the genesis of metabolic diseases.