Bin-Jaliah et al. [63] reported that insulin-induced hypoglycemia increased spontaneous ventilation in rats, an effect that was abolished in CSN-sectioned animals, but that hypoglycemia per se was unable to alter CSN frequency, suggesting that the effects of insulin-induced hypoglycemia were mediated only by insulin and not by hypoglycemia. The gene discussed is INS; the disease is Hypoglycemia.