In addition, in concordance with the blunting produced by chronic hyperleptinemia, animals submitted to longer periods of exposure to hypercaloric diets—8 weeks of HF diet [88], 16 weeks of HF diet [89], and 25 weeks of HF-high sucrose diet [16]—exhibited decreased basal ventilation and decreased responses to hypoxia, as well as the genetic model, the obese Zucker rat, a model that lacks the gene coding for the Ob-R leptin receptor [88]. This evidence concerns the gene LEPR and hydrops fetalis.