All MEUB triggering changes such as cell killing, subG1 accumulation, apoptosis (annexin V detection, pancaspase activation, and PARP cleavage), oxidative stress (ROS, MitoSOX, and MMP), and DNA damage (γH2AX and 8-oxodG) in oral cancer cells were suppressed by NAC pretreatment. Here, ANXA5 is linked to lip and oral cavity carcinoma.