TNF and Sepsis: Continuous blood purification showed significant improvement in the treatment of acute renal failure, acute respiratory distress syndrome, sepsis, and MODS.[7] Early blood purification can ameliorate immune function and maintain homeostasis by removing inflammatory mediators such as TNF, IL-10, IL-6, and IL-8 in patients with sepsis.[8] Considering the cascading effect of inflammation in SAP, high-volume hemofiltration (HVHF) treatment in SAP patients has increased progressively.