GPC3 and neoplasm: Glypican-3 is highly expressed in fetal epithelium, weakly expressed or absent in embryonic epithelial cells, but not expressed in small cell tumor cells.[17] In routine immunohistochemical detection of HB, the intensity and sensitivity of glypican-3 is higher than that of AFP and it has been reported to be an excellent marker for the diagnosis of infantile HB.[18]