TGF-β1 is the core factor in promoting fibrosis, and its expression level is closely related to the occurrence of DKD.[25] Furthermore, an abnormal glomerular filtration barrier caused by podocyte injury plays an important role in the occurrence and development of DKD.[26] Li et al[27] have reported that LDP can protect the kidneys of diabetic nephropathy rats by increasing the expression of nephrin and podocin in podocytes. This evidence concerns the gene TGFB1 and diabetic kidney disease.