NPHS2 and diabetic kidney disease: TGF-β1 is the core factor in promoting fibrosis, and its expression level is closely related to the occurrence of DKD.[25] Furthermore, an abnormal glomerular filtration barrier caused by podocyte injury plays an important role in the occurrence and development of DKD.[26] Li et al[27] have reported that LDP can protect the kidneys of diabetic nephropathy rats by increasing the expression of nephrin and podocin in podocytes.